Doc. Dr. Janez Valant

[ email | bibliography ]

My main research activity is studying interactions between nanoparticles and biological systems. I focus on linkage between cell membranes alterations and oxidative stress. I also study cellular responses to in vivo nanoparticle exposure with proteomic tools.

My research interests are also in:

  • biomarkers,
  • oxidative stress,
  • lipid peroxidation,
  • cell membrane stability,
  • proteomic tools,
  • physical and chemical properties of nanoparticle suspensions.

Methods and machines I specialize in::

  • Microscopy,
  • Spectrophotometry,
  • Fluorimetry,
  • Proteomics,
  • Cell membrane stability (AO/EB),
  • Lipid peroxidation,
  • Lysosomal membrane stability,
  • Metabolic activity.
Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes
Drašler B, Drobne D, Novak S, Valant J, Boljte S, Otrin L, Rappolt M, Sartori B, Iglič A, Kralj-Iglič V, Šuštar V, Makovec D, Gyergyek S, Hočevar M, Godec M, Zupanc J
[ pdf ] [ site ] International Journal of Nanomedicine

Acclimation of Tetrahymena thermophila to bulk and nano-TiO2 particles by changes in membrane fatty acids saturation
Rajapakse K, Drobne D, Valant J, Vodovnik M, Levart M, Marinšek-Logar R
[ pdf ] [ site ] Journal of Hazardous Materials

Effect of ingested titanium dioxide nanoparticles on the digestive gland cell membrane of terrestrial isopods
Valant J, Drobne D, Novak S
[ pdf ] [ site ] Chemosphere

Cell membrane integrity and internalization of ingested TiO2 nanoparticles by digestive gland cells of a terrestrial isopod
Novak S, Drobne D, Valant J, Pipan-Tkalec Ž, Pelicon P, Vavpetič P, Grlj N, Falnoga I, Mazej D, Remškar M
[ pdf ] [ site ] Environmental Toxicology and Chemistry

Internalization of Consumed TiO2 Nanoparticles by a Model Invertebrate Organism
Novak S, Drobne D, Valant J, Pelicon P
[ pdf ] [ site ] Journal of Nanomaterials

Biological reactivity of TiO2 nanoparticles assessed by ex vivo testing
Valant J and Drobne D
[ pdf ] [ site ] Protoplasma

The importance of a validated standard methodology to define in vitro toxicity of nano-TiO2
Valant J, Iavicoli I, Drobne D
[ pdf ] [ site ] Protoplasma

Experimental evidence for the interaction of C-60 fullerene with lipid vesicle membranes
Zupanc J, Drobne D, Drašler B, Valant J, Iglič A, Kralj-Iglič V, Makovec D, Rappolt M, Sartori B, Kogej K
[ pdf ] [ site ] Carbon

Biological Reactivity of Nanoparticles: Mosaics from Optical Microscopy Videos of Giant Lipid Vesicles
Zupanc J, Drobne D, Erdogmus D, Bas E, Valant J, Dobnikar A
[ pdf ] [ site ] Journal of Biomedical Optics

Use of a modified Allium test with nano TiO2
Klančnik K, Drobne D, Valant J, Dolenc Koce J
[ pdf ] [ site ] Ecotoxicology and Environmental Safety

A new approach to analyse effects of nanoparticles on lipid vesicles
Zupanc J, Valant J, Drobne D, Kralj-Iglič V, Iglič A
[ pdf ] [ site ] International Journal of Biomedical Nanoscience and Nanotechnology

Toxicity of abamectin to the terrestrial isopod Porcellio scaber (Isopoda, Crustacea)
Kolar L, Jemec A, van Gestel CAM, Valant J, Hrženjak R, Kožuh Eržen N, Zidar P
[ pdf ] [ site ] Ecotoxicology

Hazardous potential of manufactured nanoparticles identified by in vivo assay
Valant J, Drobne D, Sepčić K, Jemec A, Kogej K, Kostanjšek R
[ pdf ] [ site ] Journal of Hazardous Materials

Long-term Hg pollution induced Hg tolerance in the terrestrial isopod Porcellio scaber (Isopoda, Crustacea)
Lapanje A, Drobne D, Nolde N, Valant J, Hubad B, Lešer V, Rupnik M
[ pdf ] [ site ] Environmental Pollution

Lysosomal membrane stability in laboratory- and field-exposed terrestrial isopods Porcellio scaber (Isopoda, Crustacea)
Nolde N, Drobne D, Valant J, Padovan I, Horvat M
[ pdf ] [ site ] Environmental Toxicology and Chemistry